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Myoelectric and neural prosthetic devices frequently fail in daily clinical use despite laboratory success, a persistent translational gap driven by domain shift, the non-stationary nature of biological signals arising from neural…
ObjectiveTo investigate brain structural and functional alterations in diarrhea-predominant irritable bowel syndrome (IBS-D) and their associations with affective symptoms using multimodal magnetic resonance imaging (MRI).Methods53 IBS-D…
Stanford researchers have discovered that children who struggle persistently with math may have underlying differences in how their brains manage problem-solving strategies. Children with developmental dyscalculia were slower to switch…
How does the human brain wire its reward and motor centers before birth? Using 3D genome sequencing across nearly 287,000 brain cells, UCLA scientists mapped the developing basal ganglia from mid-pregnancy to infancy, pinpointing how spiny…
Words vs. numbers: A University of Tokyo study reveals that adults with autism spectrum disorder are strongly influenced by positive or negative verbal framing—such as "possible" versus "unlikely"—rather than underlying percentages when…
Does Alzheimer's start outside the brain? Gladstone Institutes researchers mapped the first atlas of 92 blood proteins that cross the blood-brain barrier, discovering that the barrier shuts down the import of protective liver proteins…
Crows may be even smarter than we thought, and their brains are astonishingly fast. Researchers at the University of Tübingen discovered that crows can make visual decisions twice as quickly as humans and monkeys, taking just 235…
Quantitative susceptibility mapping (QSM) returns the net susceptibility of each voxel. When paramagnetic and diamagnetic materials coexist, their opposing contributions can cancel, and QSM cannot recover them separately. Magnetic…
Predicting audience responses to dynamic media remains a significant challenge in neuromarketing and neuroforecasting. Intersubject correlation (ISC) has been proposed to address this need by quantifying the temporal similarity of neural…
BackgroundTraditional ambulatory electroencephalography (EEG) and inpatient epilepsy monitoring unit (EMU) admissions face significant operational limitations including: short recording windows (typically 24–72 h), high costs, technician…
Why does artificial touch fade over time? Penn State engineers used fNIRS brain imaging to solve sensory habituation during transcutaneous nerve stimulation, discovering a 5-second pulse protocol that maintains a stable sense of touch…
Ever jolt awake with a racing heart just as you drift off? A study in PLOS Mental Health reveals that frequent hypnic jerks—or sleep starts—are not simple muscle twitches, but markers of anxiety, insomnia severity, and nervous system…
Why does brain volume loss in multiple sclerosis follow distinct patterns? An MRI study of 2,187 patients reveals that atrophy originates in metabolically exhausted network hubs—including the thalamus and sensorimotor cortices—spreading…
When sleep invades wakefulness: An EEG study of 84 Parkinson’s patients reveals that sleep-like slow brain waves intrude into daytime consciousness, directly tracking with hallucinations and cognitive decline while offering a potential…
A surprising study of more than 4,500 older adults found that people who were overweight or obese when diagnosed with dementia had a 16% to 27% lower risk of death than those at a normal weight. Researchers suspect that extra energy and…
Descending pain control dynamically regulates nociceptive transmission through brainstem and spinal circuits according to behavioral and physiological demands. Within this system, accumulating evidence identifies hypothalamic orexin…
ObjectiveTo investigate APART-QSM-derived paramagnetic susceptibility (χpara) alterations in hippocampal, medial temporal, and subcortical regions in maintenance hemodialysis patients with end-stage renal disease (ESRD).MethodsThis…
Reconstructing the wiring rules of the neocortical microcircuit ideally requires simultaneous electrophysiological access to many neighboring neurons together with a precise record of the stimuli that probe their connections. This dataset…
Assistive technologies (AT) serve as fundamental tools for rehabilitation because they help people with neurological or physical disabilities to restore their abilities, independence and their overall life satisfaction. Existing AT control…
ObjectiveThis systematic review and meta-analysis of randomized controlled trials aims to analyze the efficacy of mindfulness-based interventions and biofeedback on headache frequency, pain intensity, headache-related disability…
IntroductionBovine spongiform encephalopathy (BSE) includes classical BSE (C-BSE) and two atypical forms, high-type (H-BSE) and low-type (L-BSE). Compared with C-BSE, the peripheral distribution and tissue tropism of atypical BSE remain…
New research involving more than 440,000 Americans links cannabis use to increased cardiovascular risk, with occasional users showing 40% higher odds of reporting a history of stroke. The findings suggest that even infrequent marijuana use…
Meet the brain's trash compactor: UVA Health researchers discovered that the CASS4 risk gene directs microglia to tightly pack and contain toxic amyloid plaques, proving Alzheimer's risk operates directly through immune defenses rather…
Can an infection in youth seed Alzheimer's in old age? FAU and TUM scientists investigate a "cellular long-term memory" in neurons and microglia, where damaged long-lived RNA molecules leave brain cells primed for neurodegenerative…
Is cannabis during pregnancy truly risk-free? A UC Merced study of over 2 million births in the Annals of Epidemiology finds women with cannabis use disorder face triple the risk of postpartum psychiatric emergencies, alongside a 40% surge…
How does the human placenta form in the earliest, hidden days of pregnancy? Columbia University researchers created a 3D stem-cell model that self-assembles into placental tissue and lacunae, revealing the molecular triggers behind…
Most psychedelic journeys don't happen in hospital clinics. Backed by $8.5 million in ARPA-H funding, UCSF neuroscientists led by Robin Carhart-Harris launched CANOPY—a global project tracking 3,000 real-world psychedelic users with remote…
BackgroundLow-intensity focused ultrasound (LIFU) is a non-invasive neuromodulation technique that combines millimeter-scale spatial precision with access to cortical and deep targets — including the thalamus, basal ganglia, amygdala, and…
Narcolepsy is a chronic sleep–wake disorder characterized by hypocretin (HCRT) deficiency, most commonly resulting from immune-mediated mechanisms targeting HCRT-producing neurons in the lateral hypothalamus. Although narcolepsy affects…
The review focuses on neuronal regeneration in the central nervous system and the inhibition of regeneration in the CNS, such as glial scar formation, which is a crucial mechanism of extrinsic inhibition of regeneration.…
Microtubule dysfunction has been implicated in axonal transport failure, synaptic degeneration, and neuronal loss in Alzheimer’s disease, yet its position within the disease process remains unresolved. This critical narrative review…
Sleep disturbance, chronic pain, and substance use disorders are highly prevalent conditions that frequently co-occur and exacerbate one another. Although traditionally studied as distinct clinical entities, growing evidence suggests they…
BackgroundLowering intraocular pressure (IOP) is the only proven treatment for glaucoma, yet many patients progress despite adequate IOP control. Evidence for citicoline, a candidate neuroprotectant, is inconclusive and relies mainly on…
PurposeTo evaluate the visual field performance of DIMS TED spectacle lens, an enhanced Defocus Incorporated Multiple Segments (DIMS) spectacle lens design featuring more defocus segments closer to the geometric center, higher defocus…
IntroductionDyadic sleep research has focused on romantic partners, leaving open whether nonromantic people who share a sleep space show related sleep. We examined sleep continuity and roommate concordance among undergraduate roommate…
A surprising discovery suggests that some early signs of Alzheimer’s disease may begin outside the brain. Using miniature laboratory systems made from human cells, scientists found that genetic mutations associated with inherited…
Scientists have uncovered a hidden gut-to-brain dopamine pathway that helps explain why bitter coffee and other initially unpleasant flavors can become favorites over time. The discovery reveals how the brain learns to crave certain foods…
Do psychedelics benefit all ages equally? A study of over 1,000 adults from Durham University finds that classic psychedelics like psilocybin and LSD correlate with lower anxiety and depression in younger adults, but the mental health link…
Does a good deed count if it makes you feel good? Testing the famous "Friends" paradox, Ohio State researchers discovered that people don't judge helpers for mixed motives, finding "nice" and "kind" are functionally interchangeable while…
Summary: A population-based epidemiological investigation from Trinity College Dublin finds no evidence connecting lifetime exposure to fluoridated drinking water with cognitive decline or dementia risk in older adults. Published in the…
Can a warm smile from a stranger keep loneliness at bay? University of Georgia sociologist Joseph Hermanowicz coins the term "evanescent interactions" to explain how fleeting, empathetic micro-connections validate human existence and…
How does the brain coordinate complex thought across distant regions? MIT researchers discovered that low-frequency theta waves act as the frontal cortex's master air traffic control, synchronizing neural spikes and orchestrating beta and…
How do humans and monkeys find continuous meaning in a movie? City College of New York researchers tracked eye movements and neural firing, discovering a rapid "semantic novelty signal" that bridges visual glimpses to predict scene meaning.
IntroductionThe gut microbiome influences brain function, but how chronic antibiotic exposure affects neural network organization during social behavior remains unclear. We investigated the effects of microbiome disruption on brain…
A surprising new study from UCLA suggests that a naturally occurring molecule could help breast cancer survivors overcome the frustrating brain fog and exhaustion that can linger long after treatment ends. Researchers found that women…
BackgroundMicroglia exhibit diverse responses in Alzheimer’s disease (AD), yet linking these responses to tissue pathology and disease heterogeneity remains challenging. We aimed to develop a deep-learning microglial response score…
Traditional sequence learning research relies on discrete button-press paradigms where pauses segment responses. We developed a continuous game-based adaptation of the Serial Reaction Time task and tracked neural changes in 25 participants…
IntroductionThe early postnatal period is a sensitive window for the development of social behavior, during which interactions with caregivers play a critical role in shaping brain circuits and neuropeptide systems involved in social…
A massive study of more than 120,000 older adults suggests that common osteoporosis drugs may reduce the risk of Alzheimer’s disease and other dementias by up to 24%. The surprising findings raise the possibility that medications already…
Scientists at UC San Francisco have developed a powerful new cancer therapy that remains inactive until it reaches the brain, where it switches on to attack deadly tumors. The engineered immune cells, called B-SYNC CAR-T cells, completely…
Scientists have discovered that sleep disorders are associated with structural changes in brain regions that control attention, decision-making, and emotions, potentially explaining why disrupted sleep can affect everyday thinking and…
A study of more than 17,700 US adults found that people who use cannabis in multiple forms have dramatically higher rates of daily consumption and addiction symptoms than those who stick primarily to one method. Nearly 67% of those who…
Drinking two to three cups of caffeinated coffee daily was linked to a dramatically lower risk of dementia and better cognitive functioning in a study spanning up to 43 years. The benefits appeared regardless of genetic risk, but…
A surprising discovery reveals how psilocybin, the active compound in magic mushrooms, rapidly reshapes the brain by creating new neural connections and strengthening them. Researchers found that the drug behaves differently in healthy and…
Can the pursuit of a chiseled jawline lead to self-harm? A commentary in the Journal of Adolescent Health warns that the viral "looksmaxxing" trend is driving adolescent boys toward body dysmorphia, unregulated steroids, extreme…
What makes a conversation truly click? Researchers discovered that enjoyable dialogues follow a mathematical rhythm called "pink noise", an organic ebb and flow of semantic alignment and divergence that predicts chemistry from speed dates…
Can blockbuster weight-loss medications save your memory? A review in Science by researchers at the Universities of Copenhagen and Gothenburg dissects how GLP-1 drugs affect cognitive pathways, evaluating the boundary between systemic…
The ARC machine learning framework maps brain functional connectivity between SuperAger resilience and Alzheimer’s vulnerability.